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Wisconsin Registry for Alzheimer's Prevention (WRAP)

Substudies at the Wisconsin Alzheimer's Disease Research Center

 

Participants in WRAP are eligible to participate in the following research studies at the Wisconsin Alzheimer’s Disease Research Center.

 

Neural Function and Amyloid in People at Risk for Alzheimer’s Disease (PREDICT)

The purpose of this study is to sample different biomarkers associated with AD and determine their relationship with risk factors and cognition.  PET scans will be used to image energy use and Amyloid (a protein that builds up in the brain of people with AD).  MRI scans will be used to analyze brain structure, blood flow, and activity during memory tests.  An optional lumbar puncture and blood samples will be collected to examine AD-related proteins and other health indicators.  Each of these procedures will be performed at baseline and two-years later to help us understand how the brain changes.

 

*See the study brochure for more information.

 

Who can participate?
Participants in the WRAP study with or without a family history of Alzheimer’s disease.

 

If you are interested in participating or would like to learn more about this study, please contact Caitlin Cleary, Study Coordinator, at (608) 265-0638.

 

 

PIB Imaging in People at Risk for Alzheimer’s Disease (PIPR)

PET scans will be used to image Amyloid (a protein that builds up in the brain of people with AD).  MRI scans will be used to analyze brain structure, blood flow, and activity during memory tests.  CSF and blood samples will be collected to examine AD-related proteins and other health indicators.

 

*See the study brochure for more information.

 

Who can participate?
Participants in the WRAP study with or without a family history of Alzheimer’s disease and participants in the ADRC study with a diagnosis of Mild Cognitive Impairment

 

If you are interested in participating or would like to learn more about this study, please contact Sandy Harding, Study Coordinator, at (608) 262-4760.

 


Posterior Cingulate Perfusion and Alzheimer’s Disease Risk (Merit220)

The purpose of the imaging component to the WRAP study is to study ways of detecting AD early in the disease process when treatments may be most effective. Various neuroimaging techniques are used, including functional magnetic resonance imaging (MRI) and perfusion MRI, to study the areas of the brain that are compromised early in the course of Alzheimer's disease.

 

*See the study brochure for more information.

 

Who can participate?
Participants in the WRAP study with or without a family history of Alzheimer’s disease.

 

If you are interested in participating or would like to learn more about this study, please contact Lisa Newman, Study Coordinator, at (608) 265-6581.

 

 

Amyloid Imaging in People at Risk for Alzheimer’s Disease (PiB Pilot)

Amyloid is a protein that builds up in the brain of people with Alzheimer’s Disease (AD).  It is thought that amyloid may start depositing in small amounts before the symptoms of AD are noticeable.  The purpose of this study is to use several different types of brain imaging techniques to determine if some of these changes can be detected in healthy adults with a family history of AD.

 

*See the study brochure for more information.

 

Who can participate?
Participants in the WRAP study with or without a family history of Alzheimer’s disease and participants with a diagnosis of mild Alzheimer’s disease.
  
If you are interested in participating or would like to learn more about this study, please contact Sandy Harding, Study Coordinator, at (608) 262-4760.

 

 

Metabolic Syndrome and White Matter Alterations in Preclinical Alzheimer’s Disease (METS)

The goal of this research is to determine how AD risk factors affect brain white matter and brain blood flow, and whether such changes predict the development of AD later in life. This study will  perform magnetic resonance imaging (MRI) of brain white matter in people with the metabolic syndrome, a group of cardiovascular and genetic risk factors associated with increased risk for AD. A type of MRI called diffusion tensor imaging (DTI) to assess the integrity of brain white matter, and perfusion MRI will be used to look at blood flow in the brain.

 

*See the study brochure for more information.

 

Who can participate?

Participants in the WRAP study with or without a family history of Alzheimer’s disease.

 

If you are interested in participating or would like to learn more about this study, please contact Nancy Davenport-Sis, Study Coordinator, at (608) 262-9442.